Personally I think it depends on your approach! People before me have already given some tips on DPS rush strategies, although I'd like to suggest a slower, and more careful approach. Just be sure to do this before your turn ends, as any damage taken will be saved even when restarting the battle (likely an intended consequence for this luxury). Lastly, if you have bad luck with Spotlight triggering during your first turn then you can immediately quit to the menu, continue your run, and you'll restart your run before the boss begins. Fully upgraded versions of Bimini's Let Them Expire and Griffin's Disciplined Clobber (after being spotlighted in the first phase) are what I consider the gold standard for moves that ensure quick second phase kills. The second phase is more complicated, as multi-targeting moves become far more ideal.

As for the high damage attack, examples include fully upgraded versions of the following: Longliver's Gently Eviscerate, either of Bimini's two damaging attacks, Leviat's Discipline the Insolent, Pearl's Hungry Jaws, and Griffin's Showdown Time when Spotlight triggers. Almost any method of inflicting Frail will do, but some fun examples include Accidental Malpractice with Hans and The First Born item. To elaborate a little more on the DPS rush idea, I typically run 5 party members at all times and the most common strategy I use involves inflicting frail and following up with an attack that deals over 10 damage by default.

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